Physical Frailty Is Associated with Incident Mild Cognitive
Impairment in Community-Based Older Persons
Patricia A. Boyle, PhD,_w Aron S. Buchman, MD,_z Robert S. Wilson, PhD,_wz
Sue E. Leurgans, PhD,_z and David A. Bennett, MD_z

OBJECTIVES: To test the hypothesis that physical frailty is associated with risk of mild cognitive impairment (MCI).
DESIGN: Prospective, observational cohort study.
SETTING: Approximately 40 retirement communities across the Chicago metropolitan area.
PARTICIPANTS: More than 750 older persons without cognitive impairment at baseline.
MEASUREMENTS: Physical frailty, based on four components (grip strength, timed walk, body composition, and fatigue), was assessed at baseline, and cognitive function was assessed annually. Proportional hazards models adjusted for age, sex, and education were used to examine the association between physical frailty and the risk of incident MCI, and mixed effect models were used to examine the association between frailty and the rate of change in cognition.
RESULTS: During up to 12 years of annual follow-up, 305 of 761 (40%) persons developed MCI. In a proportional hazards model adjusted for age, sex, and education, physical frailty was associated with a high risk of incident MCI, such that each one-unit increase in physical frailty was associated with a 63% increase in the risk of MCI (hazard ratio51.63; 95% confidence interval51.27–2.08). This association persisted in analyses that required MCI to persist for at least 1 year and after controlling for depressive symptoms, disability, vascular risk factors, and vascular diseases. Furthermore, a higher level of physical frailty was associated with a faster rate of decline in global cognition and five cognitive systems (episodic memory, semantic memory, working memory, perceptual speed, and visuospatial abilities).
CONCLUSION: Physical frailty is associated with risk of MCI and a rapid rate of cognitive decline in aging.

J Am Geriatr Soc 58:248–255, 2010.

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